Have a hot-key override that you can enable when you suspect something will cripple the system, so you can bring up Process Lasso and manually deal with the issue.

Some problems can hit the system without Process Lasso seeing it, so make a hot key that is bios-level monitored. (Yes, it will slow things down to start with, but at least it will be seen and responded to without having to wait for the problem to give Windows enough time for Project Lasso to put up a window!) This isn't an all-the-time facility, just something for extreme situations, when an extra level of control is needed.